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</p> <h2 class="head">低換気症候群</h2> <p>低換気症候群は、血液中の炭酸ガスが呼気で排出されず、体内で過剰になる病気である。30歳以上の男性に多く見られる。</p> <p>【原因 Cause】<br /> 多くはポリオや脳炎、慢性閉塞肺疾患、気管狭窄等の病気が原因となる。</p> <p>【症状 Symptoms】<br /> ・頭痛<br /> ・動悸<br /> ・睡眠異常<br /> ・疲労感<br /> ・不整脈<br /> ・高血圧<br /> ・チアノーゼ</p> <p>【治療 Treatment】<br /> 病気が原因となることが多いため、元になる病気の治療がまず行われる。抗うつ剤が投与される場合もある。呼吸運動をまめに行うことで改善されることもある。</p> <!--ここにアドセンス--> <p></p> <p>病態<br /> 生理的には、高二酸化炭素状態や低酸素状態が起きると、肺に分布する化学受容器が血中の酸素濃度や二酸化炭素濃度を感知して脳の呼吸中枢に信号を送り、換気を促す機能が備わっている。このような呼吸反射は自律神経系が担っている。先天性中枢性肺胞低換気症候群の患児では、覚醒時にはこの生理的な呼吸機能が保持されているが、睡眠時にはこの機能が麻痺して肺胞レベルでの酸素と二酸化炭素のガス交換が行われないため呼吸不全となる。発症には遺伝子レベルでの異常が背景にあり、中枢神経の自律神経細胞の発生に関与する転写因子遺伝子に変異があることが判明している。幸い、この変異はきわめて稀であり、目下のところ全世界で200名以下の報告例があるのみである。成人の睡眠時無呼吸症候群(英語:sleep apnea)や乳幼児突然死症候群(英語:Sudden infantile death syndrome, 略称SIDS)と誤解されがちであるが、発症の仕組みはまったく異なる。大澤らの報告(2004年)でもCCHSに特異的なPhox2Bの遺伝子異常は乳幼児突然死症候群では認められなかったとされている。</p> <p>出典: フリー百科事典『ウィキペディア(Wikipedia)』<br /> </p> <hr size="1"> </div> </div> <div id="right"> <div class="sidebar"> <div 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